Toxicity testing: Non-animal approaches and safety science

Applying exposure science to increase the utility of non-animal data in efficacy and safety testing

Non-animal methodologies within biomedical research and toxicity testing.

Laboratory animal models are limited by scientific constraints on human applicability, and increasing regulatory restrictions, driven by social concerns. Reliance on laboratory animals also incurs marked - and in some cases, prohibitive - logistical challenges, within high-throughput chemical testing programmes, such as those currently underway within Europe and the US. However, a range of non-...

Exploring new approaches to assess safety without animal testing

The 7 Amendment to the EU Cosmetics Directive has made developing non-animal approaches to assure the safety of consumer products a key business need to support future innovation. A substantial research programme was initiated by Unilever in 2004, aimed at critically evaluating the feasibility of a proposed new conceptual approach. The key aspects of this approach are: 1. Developing new risk as...

Testing Chemical Safety: What Is Needed to Ensure the Widespread Application of Non-animal Approaches?

Scientists face growing pressure to move away from using traditional animal toxicity tests to determine whether manufactured chemicals are safe. Numerous ethical, scientific, business, and legislative incentives will help to drive this shift. However, a number of hurdles must be overcome in the coming years before non-animal methods are adopted into widespread practice, particularly from regula...

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN